Publication list can also be found at Google Scholar.

Publications in 2017:

  1. Wan L*#, Chen M*, Cao J*, Dai X*, Yin Q*, Zhang J, Song SJ, Lu Y, Liu J, Inuzuka H, Katon JM, Berry K, Fung J, Ng C, Liu P, Song MS, Xue L, Bronson RT, Kirschner MW, Cui R#, Pandolfi PP#, Wei W#. The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function. Cancer Discov. 2017 Apr;7(4):424-441. (#co-corresponding authors) Pubmed | PDF
  2. Wang X, Cao W, Zhang J, Yan M, Xu Q, Wu X, Wan L, Zhang Z, Zhang C, Qin X, Xiao M, Ye D, Liu Y, Han Z, Wang S, Mao L, Wei W, Chen W. A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination. EMBO J. 2017 May 2;36(9):1243-1260.
  3. Wu F, Dai X, Gan W, Wan L, Li M, Mitsiades N, Wei W, Ding Q, Zhang J. Prostate cancer-associated mutation in SPOP impairs its ability to target Cdc20 for poly-ubiquitination and degradation. Cancer Lett. 2017 Jan 28;385:207-214.

Publications in 2016:

  1. Shao R*, Liu J*, Yan G, Zhang J, Han Y, Guo J, Xu Z, Yuan Z, Liu J, Malumbres M, Wan L#, Wei W#, Zou W#. Cdh1 regulates craniofacial development via APC-dependent ubiquitination and activation of Goosecoid. LID – 10.1038/cr.2016.51 [doi]. Cell Res 2016. (#co-corresponding authors) Pubmed | PDF
  2. Liu J*, Wan L*, Liu J, Yuan Z, Zhang J, Guo J, Malumbres M, Liu J, Zou W, Wei W. Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner. Cell Discovery 2016; 2 :15044. (*co-first authors)
  3. Lin S, Lu S, Mulaj M, Fang B, Keeley T, Wan L, Hao J, Muschol M, Sun J, Yang S. Monoubiquitination Inhibits the Actin Bundling Activity of Fascin. J Biol Chem. 2016 Dec 30;291(53):27323-27333.
  4. Li X, Dai X, Wan L, Inuzuka H, Sun L, North BJ. Smurf1 regulation of DAB2IP controls cell proliferation and migration. LID – 10.18632/oncotarget.8424 [doi]. Oncotarget 2016.

Publications before 2016:

  1. Cao J*, Dai X*, Wan L*, Wang H, Zhang J, Goff PS, Sviderskaya EV, Xuan Z, Xu Z, Xu X, Hinds P, Flaherty KT, Faller DV, Goding CR, Wang Y, Wei W, Cui R. The E3 ligase APC/CCdh1 promotes ubiquitylation-mediated proteolysis of PAX3 to suppress melanocyte proliferation and melanoma growth. Sci Signal. 2015 Sep 1;8(392):ra87. (*co-first authors) Pubmed | PDF
  2. Wan L, Tan M, Yang J, Inuzuka H, Dai X, Wu T, Liu J, Shaik S, Chen G, Deng J, Malumbres M, Letai A, Kirschner MW, Sun Y & Wei W. APCCdc20 Suppresses Apoptosis through Targeting Bim for Ubiquitination and Destruction. Developmental Cell. 2014 May 27;29(4):377-391. Pubmed | PDF
  3. Wan L*, Zou W*, Gao D, Inuzuka H, Fukushima H, Berg AH, Drapp R, Shaik S, Hu D, Lester C, Eguren M, Malumbres M, Glimcher LH & Wei W. Cdh1 Regulates Osteoblast Function through an APC/C-Independent Modulation of Smurf1. Molecular Cell. 2011 Dec 9;44(5):721-33. (*co-first authors) Pubmed | PDF
  4. Cao J *, Wan L *, Hacker E, Dai X, Lenna S, Jimenez-Cervantes C, Wang Y, Leslie NR, Xu GX, Widlund HR, Ryu B, Alani RM, Dutton-Regester K, Goding CR, Hayward NK, Wei W & Cui R. MC1R is a potent regulator of PTEN after UV exposure in melanocytes. Molecular Cell. 2013 Aug 22;51(4):409-22. (*co-first authors) Pubmed | PDF
  5. Papa A, Wan L, Bonora M, Salmena L, Song MS, Hobbs RM, Lunardi A, Webster K, Ng C, Newton RH, Jlenia G, Ito K, Knoblauch N, Turka LA, Beck AH, Pinton P, Bronson R, Wei W & Pandolfi PP. Cancer-associated PTEN mutants act in a dominant negative manner to suppress PTEN protein function. Cell. 2014 Apr 24;157(3):595-6104. Pubmed | PDF
  6. Fukushima H *, Ogura K *, Wan L *, Lu Y *, Li V, Gao D, Liu P, Lau AW, Wu T, Kirschner MW, Inuzuka H & Wei W. SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression. Cell Reports 2013 Aug 29;4(4):803-16. (*co-first authors) Pubmed | PDF
  7. Zhang J *, Wan L *, Dai X, Sun Y & Wei W. Functional characterization of Anaphase Promoting Complex (APC) E3 ubiquitin ligases in tumorigenesis. Biochimica et Biophysica Acta: Reviews on Cancer. 2014 Feb 22;1845(2):277-293. (*co-first authors) Pubmed | PDF
  8. Wang Z, Dai X, Zhong J, Inuzuka H, Wan L, Li X, Wang L, Ye X, Sun L, Gao D, Zou L, Wei W. SCF(beta-TRCP) promotes cell growth by targeting PR-Set7/Set8 for degradation. Nat Commun 2015; 6 :10185 LID-.1038/ncomms10185
  9. Liu P, Begley M, Michowski W, Inuzuka H, Ginzberg M, Gao D, Tsou P, Gan W, Papa A, Kim BM, Wan L, Singh A, Zhai B, Yuan M, Wang Z, Gygi SP, Lee TH, Lu KP, Toker A, Pandolfi PP, Asara JM, Kirschner MW, Sicinski P, Cantley L & Wei W. Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus. Nature. 2014 Apr 24;508(7497):541-5.
  10. Inuzuka H, Gao D, Finley LW, Yang W, Wan L, Fukushima H, Chin YR, Zhai B, Shaik S, Lau AW, Wang Z, Gygi SP, Nakayama K, Teruya-Feldstein J, Toker A, Haigis MC, Pandolfi PP, Wei W. Acetylation-dependent regulation of Skp2 function. Cell. 2012 Jul 6;150(1):179-93.
  11. Inuzuka H, Shaik S, Onoyama I, Gao D, Tseng A, Maser RS, Zhai B, Wan L, Gutierrez A, Lau AW, Xiao Y, Christie AL, Aster J, Settleman J, Gygi SP, Kung AL, Look T, Nakayama KI, DePinho RA, Wei W. SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature. 2011 Mar 3;471(7336):104-9.
  12. Liu P, Gan W, Inuzuka H, Lazorchak AS, Gao D, Arojo O, Liu D, Wan L, Zhai B, Yu Y, Yuan M, Kim BM, Shaik S, Menon S, Gygi SP, Lee TH, Asara JM, Manning BD, Blenis J, Su B & Wei W. Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis. Nature Cell Biology. 2013 Nov;15(11):1340-50.
  13. Liu J *, Wan L *, Liu P *, Inuzuka H, Liu J, Wang Z & Wei W. SCFβ-TRCP-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway. Oncotarget. 2014 Apr;5(4):1026-37. (*co-first authors)
  14. Zhong J *, Shaik S *, Wan L *, Tron AE, Wang Z, Sun L, Inuzuka H & Wei W. SCFβ-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration. Oncotarget. 2013 Dec;4(12):2339-53. (*co-first authors)
  15. Shaik S, Nucera C, Inuzuka H, Gao D, Garnaas M, Frechette G, Harris L, Wan L, Fukushima H, Husain A, Nose V, Fadda G, Sadow PM, Goessling W, North T, Lawler J, Wei W. SCFβ-TRCP  suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2. The Journal of Experimental Medicine. 2012 Jun 18;
  16. Fukushima H, Matsumoto A, Inuzuka H, Zhai B, Lau AW, Wan L, Gao D, Shaik S, Yuan M, Gygi SP, Jimi E, Asara JM, Nakayama K, Nakayama KI, Wei W. SCF(Fbw7) Modulates the NFκB Signaling Pathway by Targeting NFκB2 for Ubiquitination and Destruction. Cell Reports. 2012 May 31; 1 (5) :434-443.
  17. Gao D, Inuzuka H, Tan MK, Fukushima H, Locasale JW, Liu P, Wan L, Zhai B, Chin YR, Shaik S, Lyssiotis CA, Gygi SP, Toker A, Cantley LC, Asara JM, Harper JW, Wei W. mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR. Molecular Cell. 2011 Oct 21;44(2):290-303.
  18. Gao D, Wan L, Inuzuka H, Berg AH, Tseng A, Zhai B, Shaik S, Bennett E, Tron AE, Gasser JA, Lau A, Gygi SP, Harper JW, DeCaprio JA, Toker A, Wei W. Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction. Molecular Cell. 2010 Sep 10;39(5):797-808.
  19. Inuzuka H, Tseng A, Gao D, Zhai B, Zhang Q, Shaik S, Wan L, Ang XL, Mock C, Yin H, Stommel JM, Gygi S, Lahav G, Asara J, Xiao ZX, Kaelin WG Jr, Harper JW, Wei W. Phosphorylation by Casein Kinase I Promotes the Turnover of the Mdm2 Oncoprotein via the SCF(beta-TRCP) Ubiquitin Ligase. Cancer Cell, 2010 Aug 9;18(2):147-59.
  20. Wang L *, Zhang J *, Wan L *, Zhou X, Wang Z, Wei W. Targeting Cdc20 as a novel cancer therapeutic strategy. Pharmacology & Therapeutics (2015), (*co-first authors)
  21. Gao, D *, Wan, L * & Wei, W. Phosphorylation of Rictor at Thr1135 impairs the Rictor/Cullin-1 complex to ubiquitinate SGK1, Protein & Cell. 2010 Oct;1(10):881-5. (*co-first authors)
  22. Zhang J, Wan L, North BJ, Inuzuka H & Wei W. The Role of APC E3 Ubiquitin Ligase Complex in Tumorigenesis. SCF and APC E3 Ubiquitin Ligases in Tumorigenesis. 89-111. (Book chapter)
  23. Lau AW, Inuzuka H, Fukushima H, Wan L, Liu P, Gao D, Sun Y & Wei W. Regulation of APC(Cdh1) E3 ligase activity by the Fbw7/cyclin E signaling axis contributes to the tumor suppressor function of Fbw7. Cell Research. 2013 Jul;23(7):947-61.
  24. Wang Z, Wan L, Zhong J, Inuzuka H, Liu P, Sarkar FH, Wei W. Cdc20: a potential novel therapeutic target for cancer treatment. Current Pharmaceutical Design. 2013;19(18):3210-4.
  25. Wang Z, Inuzuka H, Zhong J, Fukushima H, Wan L, Liu P, Wei W. DNA damage-induced activation of ATM promotes β-TRCP-mediated Mdm2 ubiquitination and destruction. Oncotarget. 2012 Sep;3(9):1026-35.
  26. Wang Z, Inuzuka H, Zhong J, Wan L, Fukushima H, Sarkar FH, Wei W. Tumor suppressor functions of FBW7 in cancer development and progression. FEBS Letter. 2012 May 21; 586 (10) :1409-18.
  27. Wang Z, Fukushima H, Inuzuka H, Wan L, Liu P, Gao D, Sarkar FH, Wei W. Skp2 is a promising therapeutic target in breast cancer. Frontiers in Oncology. 2012 Jan 4;1(57).
  28. Wang Z, Gao D, Fukushima H, Inuzuka H, Liu P, Wan L, Sarkar FH, Wei W. Skp2: A novel potential therapeutic target for prostate cancer. Biochimica et Biophysica Acta: Reviews on Cancer. 2012 Jan;1825(1):11-7.
  29. Wang Z, Inuzuka H, Fukushima H, Wan L, Gao D, Shaik S, Sarkar FH, Wei W. Emerging roles of the FBW7 tumour suppressor in stem cell differentiation. EMBO Reports. 2011 Dec 23;13(1):36-43.
  30. Wang Z, Fukushima H, Gao D, Inuzuka H, Wan L, Lau AW, Liu P, Wei W. The two faces of FBW7 in cancer drug resistance. 2011 Nov;33(11):851-9.
  31. Gao D, Inuzuka H, Korenjak M, Tseng A, Wu T, Wan L, Kirschner MW, Dyson N, Wei W. Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways. Molecular Biology of the Cell, 2009 Jul;20(14):3305-16.
  32. Wan L, Liang X & Huang Y. Characterization of the ATPase activity of a novel chimeric fusion protein consisting of the two nucleotide binding domains of MRP1, Archives of Biochemistry and Biophysics. 2009 May 15;485(2):102-8.
  33. Yang H, Wan L, Song F, Wang M, Huang Y. Palmitoylation modification of Galpha(o) depresses its susceptibility to GAP-43 activation. The International Journal of Biochemistry & Cell Biology. 2009 Jul;41(7):1495-501.